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Pancreatitis and hepatitis in an anabolic user often result from hypercalcemia and a general hypertensive crisisresulting in increased renal acid production. Hyperkalemia and hepatic disease are common side effects of use of anabolic-androgenic steroids (AAS) and are the primary risk factors for anabolic-androgenic liver disease. In anabolic-androgenic hepatitis the primary etiology is associated with the presence of serum testosterone in anabolic use, and secondary infection of the hepatocytes and a progressive progression to liver failure. In anabolic-androgenic hepatitis the acute pathogenesis is often associated with a hyperkalemia and a progressive liver failure secondary to a prolonged exposure to liver damage. The acute process of anabolic hepatitis, when chronic, can be severe with progressive liver damage and failure to recover. Longer term toxicity and mortality, therefore, may be related to the presence of high doses of testosterone in anabolic user. A detailed review of all relevant information is included as a section in this article in Appendix I. Hepatic damage and complications [7] Exposure to liver damage after chronic use of AAS is a well-recognised feature associated with use of anabolic steroids [8]. During this process both the acute and chronic effects of steroid toxicity have been identified, and these effects may represent direct effects on the liver and the hepatocytes or may result from indirect effects upon the organism. Exposure to excess amounts of alcohol [9] Exposure to alcohol can cause the liver, resulting in the development of a progressive liver failure syndrome characterized by chronic hepatitis, fibrosis and cirrhosis. Alcoholism is one of the major causes of liver disease and is associated with an increased risk of cardiovascular disease and cancer (see box S1). Liver transplantation, liver transplantation after AAS use and the use of liver transplantation after AAS toxicity all represent an option for dealing with hepatosplenomegaly, fibrosis, and cirrhosis (see box S2). Toxicity and toxicity-related liver disease [10] Chronic use of anabolic steroids can result in liver damage which is the principal reason for the deaths arising from use of, or subsequent complications of, AAS [11]. The risk from chronic use of anabolic steroids is increased as the dose, frequency and duration of use are increased. The incidence of liver diseases after steroid administration are very high, and many of them have been caused by the use of AAS, but these have caused the greatest health problems (Box S1). Box S Similar articles:
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